Friday, February 24, 2012

In the 1920s and 30s, the first experiments ...

Steroids History has long been known that the testes are responsible for secondary male characteristics and features. In ancient Greek times, the testes of animals such as oxen were eaten before the event to improve performance in games. In 1849, scientist discovered Berthhold largely through experiments with Cockerals, that eggs were blood related because of secondary male characteristics. This study included castration of these animals and the various studies estimate that the biological effects lasix without prescritpion of this procedure was to them. In the 1920s and 30s, the first in isolation


molecules with the bulls. Then, from 1948-1954, the company CIBA Searle and went on sythesize and discover one thousand anabolic steroids and testosterone derivatives. Modern endocrinology, undoubtedly formed in this early study.infant immune system Needless to say, the selection of testicular testosterone molecule was the first step in discovering the first


message about using testosterone to improve physical strength were the Germans. There are rumors that the Germans are widely used testosterone during the Second World War as an opportunity to increase aggression troops Nazis. In sports the border, the Russians were the first to use testosterone to increase sports in the 50's and 60's. This is obviously because they have broken world weightlifting records at this time. Testosterone Molecule At the time, CIBA and SEARLE still holds one thousand anabolic steroids in the laboratory. In fact, in the middle of the 1950s, most anabolic steroids and testosterone derivatives was discovered and manufactured. Anabolic steroids are testosterone-based analogs produced synthetically, and are intended for the production of anabolic androgenic and effects. Testosterone is the primary male hormone. It is produced in small quantities in the adrenal glands, but most of the men's testosterone produced by Leydig cells in the testes. At puberty, when most of the effects of testosterone there. Anabolic steroids like testosterone effects are usually felt shoulder extension and increase overall muscle size. Sexual maturation is generally accompanied by growth spurt, resulting from testosterone in combination with anabolic effect produced by the pituitary


. Anabolic steroids and stacks of different compounds of productivity used by many athletes to repeat this type of pubescent hormonal output to increase sports performance or simply for cosmetic improvement and muscular physique. Anabolic steroids are controlled drugs and only by prescription. However, many people buy them on the black market. Molecules of testosterone, along with the typical anabolic steroids will appear anabolic and androgenic effects. Androgenic effects associated with secondary male characteristics such as sex drive, tone of voice and facial hair growth. Androgenic effects are most often correlated with steroid side effects by conversion to estrogen (aromatization), conversion to DHT (dihydrotestosterone) and closed the hypothalamus / testicular axis. The last of these means that exogenous steroids reduce their own opinion of anabolic steroids. Now, the anabolic effects associated with enhanced protein synthesis effects or muscle building properties of these compounds are not usually associated with


In the early years of development, researchers hope that a purely anabolic forms can be developed to assist aging with compounds that increase muscle power and strength, while slowing aging. In fact, many circles extend the use of doctor prescribed testosterone and growth hormone replacement for that purpose today. Chemists CIBA and SEARLE, together with the work of Dr. Dianabola Zihler quickly found out that replacing a hydrogen atom on steroids 17th alpha position with a carbon atom, dramatically increase the ability of steroids to resist breakdown by the liver. This carbon atom is usually attached to methyl groups and the process known as methylation. Steroids with this chemical design is C-17 alpha alkaline orally. Steroids of this particular configuration is also considered by many the most powerful as well. However, one of the main drawbacks of this chemical design that liver toxicity is greatly increased and there is potential harmful effects on the liver. Esters were the following molecular changes are made to increase the active life of steroids in the body. Many injections that have long names, such as testosterone and testosterone enanthate tsypyonat, the configuration is broadcast. For example, when it comes to testosterone enanthate aformetioned molecules and tsypyonat which are the esters (carboxylic acid), which were chemically fused with 17-beta-hydroxyl group of the molecule of testosterone. This change makes the steroid more soluble in contrast to its normal solubility in water. The longer chain ether hand, the longer it usually takes for the connection to break into the system. Customs steroids may take four weeks to disperse, and >> << or structure may be completely free in the blood during the day. Eteryfikovani steroid drugs are usually intended for injection into the abdominal muscles. Toxicity of the liver is still a challenge to monitor and consider, but not so strong as with C-17 oral. In advanced modern world, many high-tech sports nutrition company developed a powerful productivity products that do not require a prescription and comparatively much safer than steroids for long-term use. Foods such as >> << and stimulants, as examples of clean, efficient technologies but a product for adult sports accessory. Protein supplements, cutting-edge strategies, diet and special procedures and training can significantly increase performance with very low risk for endocrine system. A. Classification of anabolic steroids by competitive metabolism. Exp Clin Endokrinol 87:125-32, 1986


2. Metabolism of anabolic androgenic steroids, Victor A. Rohozkyn, CRC Press 1991


3. The World Anabolic Review 1996 P. Grunding / M. Machman, MB Muscle Books, M. Bodingbauer, D. Selm


4. Anabolic steroids in 2000. In 2000. William Llewellyn, anabolics. com, Inc 5. Anabolic steroids in sport and exercise. In 1993. Yesalis, Charles, Human Kinetics Publishers


6. Underground steroids Handbook II. In 1989. Duchaine, D. Venice, CA: HR Technical Literature


7. Anabolic owner (5th Edition) 1990. Phillips, William Golden, CO: Mile High >> <<

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